About Me

Welcome to my blog! I am a medical doctor currently in the role of a health entrepreneur and a health coach/consultant. My blogs are focused on using a holistic approach towards healthcare. I believe patients are not just diseases but humans as a whole. Therefore, conventional treatments should be combined with alternative/natural therapies. My blogs focus on providing guidance to fix the cause of conditions and not just reduce the symptoms.

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Meaning of Anxiety: A Holistic Approach


"Our anxiety does not come from thinking about the future, but from wanting to control it." - Kahlil Gibran

What does ANXIETY mean? From my personal experience and with those that I have met, I have learned, and accepted, that stress and anxiety is as integral to our existence as bread and butter. It is WRONG to perceive anxious people as neurotic or weak, as NONE OF US is immune from it. It is also imperative for me to point out that stress and anxiety are NOT always harmful. In fact, these feelings are very crucial for our survival. They prepare us to face the uncertainties and enhance our performance in difficult tasks. So, when does this "normal" become a "disorder"? Let's find out. 

 

Objectives of this article:

  •  What anxiety disorder means

  •  How to recognize anxiety disorders

  •  Evidence-based anxiety treatment options

 

What does anxiety mean? How do you differentiate between everyday anxiety and an anxiety disorder?

An everyday anxiety and an anxiety disorder typically vary only in their frequency and severity of symptoms that is measured by the extent to which one's life is affected. A simple question that will make it clearer: Are you able to fulfill your daily responsibilities without much difficulty? If the answer is no, it is a disorder. Anxiety is a mental state of mind where our brain perceives something as a threat. That threat then transforms into physical symptoms such as sweating, fast and shallow breathing, headaches, chest pain, dizziness, shakiness, nausea. Our sympathetic nervous system takes control and stress hormone levels rise. We naturally engage in safety-seeking, comforting behaviors; we avoid circumstances that trigger stress and anxiety, which feeds on itself and reinforces the perception of threat. Over extended periods of time, this perception leads to severe physical symptoms like chronic fatigue, loss of concentration, insomnia. (Read: What is the Relationship Between Sleep, Stress and Nutrition?)


What are some of the challenges of diagnosing anxiety disorder?

In the very first meeting with the doctor, the patient's chief complaint is the physical symptoms they are experiencing, including tiredness, headaches, abdominal issues. The initial step, therefore, is to run a thorough physical examination. While it is established that anxiety causes physical symptoms, the vice versa if often very common as well where certain medical conditions lead to the development of anxiety, like lung disease, heart disease, diabetes, obesity. The other culprit is the medications that generate anxiety-like feelings. Some popular examples are steroids, decongestants, asthma and thyroid medications, and those used for the treatment of Parkinson's disease. Finally, it is important to rule out the existence of substance abuse that can cause anxiety, like alcohol and other drugs like cocaine and LSD. The next step involves checking the mental status of the patient. Why is the patient feeling unwell? Here it is important to address their lifestyle habits such as sleep, diet, exercise, personal events. While all of the factors mentioned above present as a challenge in diagnosing anxiety, the one factor that has a huge impact is the social stigma associated with being stressed and anxious. Patients find it difficult to admit to their doctors that they are struggling with anxiety; they don't want to seem vulnerable and neurotic; they feel they will not be heard seriously - their feelings will be outright dismissed. Therefore, it is extremely important for doctors to not jump to conclusions very early - they should first empathize and connect with their patients. 


Just how disabling are anxiety disorders?

Anxiety disorders are extremely underestimated in their impact on a person's daily life. And to make the matters worse, there is a huge burden of the associated social stigma. According to research, social anxiety disorder feels worse than having a high blood pressure or diabetes. Generalized anxiety disorder feels worse than the above mentioned and asthma or any sort of heart condition. The worst is the obsessive-compulsive disorder, fairing poorer than all of the above conditions, including kidney disease. Can you imagine now how disabling anxiety is? 


Is there a relationship between anxiety and depression?

Anxiety can present with symptoms that overlap with depression. Those diagnosed with an anxiety disorder will very commonly experience at least one episode of depression. Therefore, it is important for the healthcare professional to assess the presence of both. If the patient is successfully treated with antidepressants and are taken off the medications, there is an increased risk for the anxiety component to bounce back and become worse. Therefore, discontinuing treatment should be assessed with caution.


When is it recommended to meet a psychiatrist?

Psychiatric evaluation is warranted when the patient fails to respond to the interventions of the general practitioner (GP). Usually, the normal response time is between 6-8 weeks. Some factors that can complicate patient response is the co-presence of other conditions like personality disorders, bipolar disorders or substance use. 


How can it be explained to the patient that they are dealing with an anxiety disorder?

First and foremost, show empathy. It takes 2-3 consults with the doctor before a patient is willing to accept that they are indeed dealing with anxiety. When the doctor has had meaningful conversations with the patient, and the patient has come to terms with the diagnosis, then is the correct time to provide medications and written materials for the patient to familiarize themselves with the condition. It is vital to develop a mutual understanding with the patient before the doctor refers them for a psychiatric evaluation or the chances are that those patients will never return to continue treatment. 


What are some other suggestions for the patients to handle their anxiety?

While awaiting a formal diagnosis, patients are encouraged to adapt lifestyle modifications such as eating a healthy diet, exercising, minimizing alcohol intake, keeping track of caffeine intake, practicing mindfulness with meditation and breathing exercises. They can also use external health resources to learn more about their condition, which can be further discussed with their psychologist/psychiatrist.


Why is Cognitive Behavioral Therapy (CBT) most commonly recommended and what does it include?

CBT is backed by the greatest amount of research, clinical trials and meta-analyses that have concluded that it is most superior to other models in terms of its success rate. Typical CBT includes understanding the patient as a whole by asking what triggered the anxious feelings and what strategies they are implementing to cope with these feelings, and then formulating a treatment plan that is specifically tailored to their lifestyle and goals. Does the patient understand what they are going through? How do they solve their day-to-day life problems? CBT involves reshaping the patient's reasoning and thought processes to face their fears and challenge the thinking patterns. Behavioral techniques are also implemented in the treatment where the patient is gradually and increasingly exposed to their fears over time till the associated anxiety is reduced. 


When are medications necessary and which ones are recommended?

General practice guidelines state that medications are opted for when patients are severely distressed and/or not responding to other interventions. Selective Serotonin Reuptake Inhibitors (SSRIs) are the most widely recommended first-line treatment globally. The second-line class of medications is the Serotonin- Norepinephrine Reuptake Inhibitors (SNRIs). The initial treatment begins with SSRI monotherapy for 1-2 weeks, typically starting with half the dose of what is prescribed for depression, accounting for the fact that anxious and stressful patients are hypersensitive. For the next 4-6 weeks, medication response is monitored. If the response is positive, the same treatment continues for 6-12 months. If the response is negative, either the medication dose is adjusted or an alternate medication is started. Other classes of medications, such as beta blockers, benzodiazepines and antipsychotics, should NOT be used as first-line treatments due to their side effects (*Note: Medications are given in combination with CBT*).


What to look for if the patient is not responding to treatment:

Discuss with the patients about their lifestyle habits or any related factors that might be playing a role. Are they compliant with their medications? The medication dose can also be reviewed and adjusted. Are there any unhealthy/stressful situations at home or work? Patients can be encouraged to meet with their psychologist/psychiatrist more frequently to maintain the treatment momentum. Lastly, check in on any other medical conditions that the patient may be mismanaging and inducing anxiety as a result.

 

Some strategies to maintain mental health:

  • Regular exercise

  • Balanced, healthy diet

  • No smoking

  • Maintenance of a good sleep hygiene

  • Socialization  

 

Anxiety can be debilitating and distressing and bringing it to the attention of a healthcare professional should never be dismissed due to social stigmas. Why should you ever be in control of your thought processes? Anxiety disorders have a high recovery rate and they CAN be managed successfully. I encourage you to consult with your doctor if you feel your lifestyle is severely compromised due to certain fears or thoughts. If you are looking for more related resources that can help you combat anxiety, please leave your comment below and connect with me. 

Read: What is the Relationship Between Sleep, Stress and Nutrition?




References:

1. Andrews et al, British Journal of Psychiatry (1998); 173: 123-131.

2. RANZCP clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder 2018.

3. Craske, uptodate.com, Psychotherapy for generalised anxiety disorder 2018.

4. Australian Medicines Handbook 2018.

5. Maudsley prescribing guidelines in psychiatry, 13thedition, 2018.

Benefits of Omega-3 Fatty Acids: What Does the Latest Research Indicate?


 

 Omega-3 fatty acids fall under the category of polyunsaturated fats. Polyunsaturated means it remains liquid at room temperature. These fats are primarily marine and plant-based. On the other hand, the saturated fats are solid at room temperature, primarily coming from an animal source.

There are 3 types of omega-3 fatty acids: Alpha-lenoic acid (ALA), Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Out of these, ALA is an essential nutrient, which must be taken from the diet. ALA then breaks down into EPA and DHA. However, this conversion rate is quite low and therefore, it is recommended to incorporate EPA and DHA from diet and supplements.

 

To be discussed in this article:

  • Benefits of omega-3 fatty acids in heart health

  • Benefits of omega-3 fatty acids in brain health

  • Benefits of omega-3 fatty acids in eye health

  • Benefits of omega-3 fatty acids in prenatal health 

  • How to get the adequate amounts of omega-3 fatty acids

 

Benefits of Omega-3 Fatty Acid in Heart Health:

Regular intake of omega-3 fatty acids is directly linked with significant reduction in coronary heart disease and sudden cardiac arrest. It also helps lower triglyceride levels by maintaining healthy blood vessels with adequate blood pressure control. 

  • A Study of Cardiovascular Events in Diabetes: 1 gram per day of omega-3 fatty acids lead to a 18% reduction in risk of heart-related deaths.
  • Reduction of Cardiovascular Events with EPA- Intervention Trial: 4 gram per day of EPA combined with statin medication lead to a 25% decrease of cardiac-related events. 
  • Vitamin D and Omega-3 Trial: 1 gram per day of omega-3 fatty acid supplement reduced the risk of heart attacks by 28%.

 

Benefits of Omega-3 Fatty Acids in Brain Health:

DHA is found in a high concentration in brain tissue. Adequate omega-3 fatty acid supplement improves cognition and memory and reduces cognitive decline with increasing age. There is a growing body of research in psychology that supports the benefits of omega-3s in mental health conditions like Attention-Deficit Hyperactive Disorder (ADHD), Major Depressive Disorder (MDD), Bipolar Disorder, Schizophrenia and Anxiety Disorders. 

  • International Society for Nutritional Psychiatry Research: Omega-3 fatty acids can be combined with the regular medical treatment of MDD, as they have been proven to be both safe and effective in reducing the severity of MDD when taken with regular antidepressants. The most effective EPA to DHA ratio in this case is >2:1
  • Use of Omega-3s in traumatic brain injury: single dose of 3000mg of EPA+DHA given 3 times a day for the first week, for a maximum of 9000mg per day. For the second week, one dose 2 times per day for a maximum of 6000mg per day. Beyond that, one dose daily for maintenance, for a maximum of 3000mg per day. 

 

Benefits of Omega-3 Fatty Acids in Eye Health:

 Just like in the brain, DHA is highly concentrated in the eye tissue, especially in the retina. DHA plays a critical role in the development of eyes during pregnancy. Deficiency of omega-3s can be associated with dry eyes, and age-related vision problems, called macular degeneration.

 

Benefits of Omega-3 Fatty Acids in Prenatal Health:

Omega-3 fatty acids play a vital role in the development of a fetus brain and eyes. Brain development is linked with an increase in functionality of the brain parts that are involved in handling attention and physical movements. The development of the eyes is linked with an increase in visual acuity and increased functionality of photo-receptors, or the ability to see in minimal light and differentiate between specific colours. 

  • American Academy of Pediatrics: Omega-3 supplement should begin while the mother is pregnant and should continue for the child's first 2 years of life (1000 days) as the effects of omega-3s are crucial for the neurodevelopment and long-term mental health of the child. 
  • Effects of Omega-3 fatty acid on pregnancy: A study has shown that an adequate omega-3 fatty acid supplement in pregnancy leads to a massive 42% risk reduction of preterm birth before 34 weeks, 11% risk reduction of preterm birth before 37 weeks and a 10% risk reduction of a baby born with low birth weight (less than 5.5lbs).

 

How to Get the "Super Nutrient" Omega-3 Fatty Acids:

While the daily recommendation is 250mg of EPA+DHA, new research is beginning to show that we might need more than that. It has been concluded that while the general population is taking adequate amounts of ALA in their diets, the level of EPA and DHA is very, very low (the good stuff that we actually need!).

  • Start with knowing your needs of omega-3s: A simple blood test can be easily carried out at home, similar to diabetics checking blood sugar levels at home on a strip. This sample can then be sent to the lab to measure the level of omega-3 fatty acids in your body: low level corresponds to anything below 4%, intermediate is between 4-8%, and a desirable level of omega-3s should be between 8-12%.
  • 8 ounces of seafood per week (2-3 servings per week) provides an average of 250mg EPA+DHA per day. Include fatty fish like salmon and herring.
  • When you are grocery shopping, look for food items that are especially fortified with omega-3 fatty acids.
  • Omega-3 fatty acid supplements: fish oil gels, flavoured gummies, liquid syrup, like cod liver oil, that can be given to children. Check the supplement label for the serving size and the amount of EPA+DHA present (listed separately). As a general rule, the sum of EPA+DHA should equal to at least 900mg.
  • Options of vegetarians/vegans: marine microalgae, chia seeds, flax seeds, walnuts, soy beans are some of the options. 
It is best to take omega-3 fatty acids from multiple resources for a more balanced nutrition. 

 

Omega-3 fatty acids sit at the top of the list of those nutrients that have gained immense popularity in recent times and rightfully so, as more emerging research data support the benefits on fetus development, heart health, brain health and eye health, covering all age groups of the population, beginning from pregnancy. What is your requirement of omega-3 fatty acid intake? And how do you make sure you are getting enough of that good stuff? Leave your comments below and let me know!


References:

 1. Essential fatty acids. Oregon State University,Linus Pauling Institute, Micronutrient Information Center website.https://lpi.oregonstate.edu/mic/other-nutrients/essential-fatty-acids. Updated May 2019.

 2.Fatty acids and cholesterol subcommittee. US Department of Agriculture, Nutrition Evidence Systematic Review website. https://nesr.usda.gov/fatty-acids-and-cholesterol-subcommittee.

3.EslickGD, Howe PR, Smith C, Priest R, Bensoussan A. Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol. 2009;136(1):4-16. 

4.Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr. 2002;76(2):326-330. 

5.Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens. 2014;27(7):885-896. 

6.Bowman L, Mafham M, Wallendszus K, et al.; ASCEND Study Collaborative Group. Effects of n-3 fatty acid supplements in diabetes mellitus. N Engl J Med. 2018;379(16):1540-1550. 

7.Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22.

 8.Manson JE, Cook NR, Lee IM, et al. Marine n-3 fatty acids and prevention of cardiovasculardisease and cancer. N Engl J Med. 2019;380(1):23-32. 

9.Chang JP, Su KP, Mondelli V, Pariante CM.Omega-3 polyunsaturated fatty acids in youths with attention deficit hyperactivity disorder: a systematic review and meta-analysis of clinical trials and biological studies.Neuropsychopharmacology. 2018;43(3):534-545. 

10.Lin PY, Huang SY, Su KP.A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression.Biol Psychiatry. 2010;68(2):140-147. 

11.McNamaraRK,WelgeJA.Meta-analysis of erythrocyte polyunsaturated fatty acids biostatus in bipolar disorder.Bipolar Disord. 2016;18(3):300-306.

12.van der Kamp WJ, Klomp DW, Kahn RS, Luijten PR, Hulshoff Pol HE.A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia.Schizophr Res. 2012;141(2-3):153-161. 

13.Gupta A Summerville G, Senter C.Treatment of acute sports-related concussion.Curr Rev Musculoskelet Med. 2019;12(2):117-123. 

14.Guu TW, Mischoulon D, Sarris J, et al.InternationalSociety for Nutritional Psychiatry Research practice guidelines for omega-3 fatty acids in the treatment of major depressive disorder.Psychother Psychosom. 2019;88(5):263-273.

15.Omega-3 protocol for brain health. Brain Health Education and Research Institutewebsite.http://www.brainhealtheducation.org/omega-3-protocol/. 

16.Schwarzenberg SJ, Georgieff MK; Committee on Nutrition. Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health. Pediatrics.2018;141(2):e20173716. 

17.AbdelhamidAS, BrownTJ, BrainardJS, et al. Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev.2020;3:CD003177. 

18.Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes forenergy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids.https://www.nal.usda.gov/sites/default/files/fnic_uploads/energy_full_report.pdf. Published 2005. 

19.US Department of Health and Human Services. 20152020 Dietary Guidelines for Americans. 8th Edition. https://health.gov/our-work/food-nutrition/2015-2020-dietary-guidelines/guidelines/table-of-contents/.Published January 7, 2016. 

20.US Department of Agriculture, Agricultural Research Service. What We Eat in America, NHANES 2015-2016: table 1. Nutrient intakes from food and beverages: mean amounts consumed per individual, by gender and age, in the United States,2015-2016. https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/1516/Table_1_NIN_GEN_15.pdf.

21.Hu Y, Hu FB,Manson JE. Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127477 participants. J Am Heart Assoc. 2019;8(19):e013543.  

22.Makrides M, Best K, Yelland L,et al.A randomized trial of prenatal n-3 fatty acid supplementation and preterm delivery.N Engl J Med.2019;381(11):1035-1045. 

23.Simmonds LA, Sullivan TR, Skubisz M,et al. Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomized controlled trial [published online February 8, 2020]. BJOG.doi:10.1111/1471‐0528.16168.


 

The Importance of Fostering a Positive Parent-Child Relationship



Perhaps the most important family relationship is between a parent and a child and rightfully so, as this relationship clearly identifies how a brand new human being is about to evolve for the rest if its life.

It is vital to recognize and involve positivity in a parent-child relationship as they impact child development throughout his/her life. As you, being a parent, indulge in this roller-coaster ride, there are strategies that can support and enhance your relationship with your child.

Objectives of this article:

  • Identify characteristics of a positive parent-child relationship

  • Discuss the science behind early childhood development

  • Outline outcomes of a parent-child relationship

  • List some useful strategies to control stress

  • Insight into developing an in-depth perspective of a parent

Before you begin reading further, try to think of words or behaviors that come to your mind when you think about what a positive parent-child relationship should be like, and remember those words as you read.

What are some characteristics of a positive parent-child relationship?

Have you ever stopped to notice how your child would perform an action and look at you in a subtle way as if they are wondering, "Mommy/Daddy, did I do this right?"?
Parents should always seek to respond to their children in a warm and sensitive manner. It is an innate need of a child to want attention and reassurance. One aspect is the emotional development of children, where they constantly seek their parents' reassurance, which can be through their body language or words. The second aspect is their physical development, where they interact with you through cuddles and hugs when they are sleepy or hungry, or burst into tears to show their pain that they got a boo-boo. All these are examples of how a child is seeking your love, comfort and warmth as they see you as their protective figure.
On the other hand, parents need to tailor their responses that is balanced between heeding to their children's demands and carefully judging, calculating and learning what kind of responses lead to a positive experience between them and their children. Parents need to think where their children stand in terms of their abilities, disabilities, challenges and overall uniqueness. It is important to maintain a positive discipline at home that enforces appropriate age-based guidelines, limitations and boundaries. In one line, your children literally tell you their story: they will, very clearly, communicate to you whether your responses are working with them or not and accordingly, you need to redirect those responses as per their need.

Brief science of early childhood development:

All children are born ready to learn, like a clean slate waiting for words to be written on it. Their genetics, and most importantly, the environment in which their relationships are nurtured shapes their personality. The development of these relationships differs vastly from family to family; how your child responds to you and what behaviors you have encouraged or punished does not have to be matched with or compared to another child. not even his/her siblings. Each child's thought processes, personality, temperament, moral and academic development stems from his/her family history, cultural beliefs and practices, and gender differences.

Outcomes of a parent-child relationship:

When children are nurtured in a positive and supportive parent-child relationship, they develop strong emotional security, they are better able to cope with challenging situations, have a positive outlook with problem solving skills, and foster healthy relationships in their own lives. Children learn the important skills of confidently engaging with others, develop appropriate societal behaviors, take initiative to resolve conflicts and have a thriving self-confidence. As children grow to become teenagers, they adapt strong leadership skills, develop a motivational personality, hone positive thoughts, are better able to cope with lifestyle changes and increasing responsibilities, have a strong sense of self and willpower. These teenagers become young adults with a good practice of self-calming behaviors who have tried and tested and adapted to stress reduction strategies. They develop a keen interest in learning novel things and perform well academically. Whereas, negative feedback combined with punishing behaviors, especially amidst outsiders or another family groups, is strongly linked with a reduction in child's self-worth and confidence.  

Stress-reduction strategies for parents:

It is a clear consensus that parenthood is stressful and demanding, which often compromises the health of the parents, which indirectly affects their relationship with their children. Implement the following to reduce stress:
  • Connect: connect and discuss with your spouse and other family members.
  • Exercise: get those feel-good hormones flowing!
  • Take a break: indulge in self-care, focus on your hobbies, enjoy nature.
  • Have fun with your child: you don't always have to be an authoritative figure to your children.
  • Daily routine: maintain a daily routine to avoid unnecessary frustration.
  • Mindfulness: incorporate meditation and breathing exercises into your busy schedule.
  • Ask for support: never hesitate to seek guidance from family, friends and community resources.

Parent's perspective:

As we close this article, there are a few questions that parents must ponder on regularly to guide their own behaviors toward their children: What are you doing that brings out a positive moment during interactions with your child? What do you do that creates stressful situations and how do you respond to it? Do you often notice how your child looks at you? When does he/she make an eye contact with you and when do they hesitate? How does your child react when you assist them with their chores? How often does he/she ask you for help and for what purpose? Can you sense any cues of frustration? How does your child communicate their frustration to you? Does he/she provide any clue to you about how they might be feeling about something? How much time do they spend on social media/watching television/using electronic gadgets? Is your child aware of what media violence is? What steps do you take to protect them from it? How is he/she keeping themselves engaged? What are their hobbies/likes/dislikes? Are they growing and developing appropriately according to their age? Are you keeping an eye on their nutritional needs?

To sum up, parenthood is the one of the greatest joys of life but not an easy task to handle. You probably are familiar with that since the time you were preparing to become a parent. Thankfully, there are certain strategies you can implement and practice in your relationship with your child that will make this beautiful journey more rewarding and less daunting.


Leave your comments below and connect with me for any questions/concerns/thoughts.


References:
1. Angela Fisher-Solomon, National Center of Early Childhood Development, Teaching and Learning
2. Jennifer Olson, National Center of Parent, Family and Community Engagement

Polycystic Ovary Syndrome Part II: Nutritional Strategies of Management


Dietary management of Polycystic Ovary Syndrome (PCOS) should focus on weight loss and modification in insulin levels.

In this article:

  • Ketogenic diets and insulin management

  • Mediterranean diet and risk reduction of metabolic syndrome and type 2 diabetes

  • Polyphenols and their role in blood sugar levels

  • Curcumin and its properties

  • Role of omega-3 fatty acids

  • Coenzyme Q10 health benefits

  • Most powerful antioxidants

  • Relationship between gut health and PCOS



Ketogenic Diets

Insulin signalling is key in the management of insulin resistance that gives rise to metabolic syndrome and type 2 diabetes. Research has shown that low-carb ketogenic diets have resulted in greater improvement of blood sugar levels in obese patients with type 2 diabetes. Additional benefits of these diets include better hormonal control, significant weight loss and improvement of fatty liver disease.

Mediterranean Diet

Mediterranean diet is composed of cereals, nuts, legumes, vegetables, fruits with significant use of extra virgin olive oil. This food composition enhances the intake of complex carbs like fiber & whole grains, minerals like selenium, iron, potassium, magnesium & calcium, vegetable proteins & polyphenols, which are micronutrients present in plant-based foods. All these together lead to better control of blood sugar levels & aim at reducing the blood pressure. The unsaturated fatty acids of healthy oils and polyphenols together work to increase HDL (good cholesterol) and decrease chronic inflammation. These effects lead to lower cholesterol and triglyceride levels and reduced fat storage, which significantly reduces the risk of metabolic syndrome and type 2 diabetes.

Polyphenols:

A research study comprising of 1133 subjects has shown that the consumption of green tea lead to decreased fasting glucose and HbA1c levels. Eleven other studies on 388 subjects have concluded that the consumption of resveratrol (plant-based polyphenol that is a strong antioxidant) significantly reduced fasting glucose, insulin, HbA1c levels in the diabetic population.
(Read the effects of green tea on sleep and stress: What is the Relationship Between Sleep, Stress and Nutrition?)

Curcumin:

Curcumin has long been known for its strong anti-inflammatory and antioxidant properties and has been widely practiced since ancient times in Indian Ayurvedic medicine. Turmeric contains roughly 10% curcuminoids that are a potent combination of curcumin, demethoxycurcumin, bis-demethoxycurcumin.In a 30-day research trial, daily supplementation with 400mg curcumin in healthy individuals lead to reduced brain aging, lowered triglyceride levels, reduced stress levels, improved liver function and an increase in antioxidant enzymes.

Omega-3 Fatty Acids:

Two comprehensive studies have shown that taking 1200-1500mg of omega-3 fatty acids over the period of 2-6 months significantly reduced free testosterone levels and lead to a better hormonal control of PCOS in obese and non-obese women. Long-term effects included lower insulin resistance, blood glucose and triglyceride levels. Other equally significant benefits of omega-3 fatty acids are: improved symptoms of chronic depression, lower inflammatory markers in blood, low cortisol (stress hormone) levels and increased brain function.

Coenzyme Q10 (CoQ10):

 In a clinical trial conducted on 60 women with PCOS that were given 100mg CoQ10 for 12 weeks, it was concluded that CoQ10 supplementation significantly reduced blood glucose levels with well-controlled insulin levels and reduced cholesterol levels with enhanced heart health.

Strong antioxidants to include in diet:

  • Vitamins A, C, D, E
  • Alpha-lipoic acid
  • Polyphenols
  • Selenium
  • Copper
  • Magnesium
  • Zinc
Antioxidants stabilize free radicals and essentially stop their damaging effects on cells and their metabolic activities. They further support detoxification, reduce fatigue and tiredness, boost mental health and are very important elements for proper functioning of the nervous system.

Gut Health:

In humans, around 90% of gut bacteria are represented by two major strains: Firmicutes (60-80%) and Bacteriodetes (15-30%). In obese women with PCOS, this ratio is imbalanced with a reduced microbial diversity. This imbalance and compromised gut health is linked with increased risk of type 2 diabetes in PCOS. Other risk factors include inflammatory bowel disease, irritable bowel syndrome, celiac disease, colorectal cancer, gut-brain axis disorders like depression, anxiety, chronic pain, fatigue, and compromised immune system (gut houses around 80% of the total immune system). In order to improve gut health, it is recommended to: increase fiber content in diet, which is naturally fermented in the gut that strengthens and diversifies gut bacteria; increase natural prebiotic intake in forms of cereals, fruits and vegetables; incorporate fermented foods like sauerkraut, kimchi, yogurt, kefir.


The nutritional strategies mentioned above are interventions that can be used in combination to synergistically enhance the health benefits while significantly reducing the health risk factors and hormonal disturbances associated with PCOS. Targeting multiple health factors with the combination of diverse nutrients mentioned above eases the challenging task of clinical management of PCOS.

Leave your thoughts and concerns in the comment section below and connect with me.




References:
1. DiSilvestro et al. Diverse effects of a low dose supplement of lipidated currcumin in healthy middle aged people. Nutr J. 2012. 11(79). doi: 10.1186/1475-2891-11-79.
2. Gholnari et al. The effects of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial. J Am Coll Nutr. 2018. 37(3):188-193.
3. Gokalp et al. Efficacy of omega-3 in the treatment of polycystic ovary syndrome. Journal of Obstetrics and Gynecology 2012. 33:289-291.
4. Liu et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized  controlled trials. Am J Clin Nutr. 2013. 98(2):340-348.
5. Liu et al. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized  controlled trials. Al J Clin Nutr. 2014. 99(6):1510-1519.
6. Mohammadi et al. Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pac J Clin Nutr 2012. 21(4): 511-518.
7. Salas-Salvado et al. Protective Effects of the Mediterranean Diet on Type  Diabetes and Metabolic Syndrome. The Journal of Nutrition 2016. 146(4): 920S-927S.
8. Dr. Nina Bailey, PhD. Igennus Healthcare Nutrition.

Polycystic Ovary Syndrome Part I: The Science Behind It


Polycystic ovary syndrome is a very common disorder that affects 5-10% of women around the globe in their reproductive years.

Many women believe that PCOS only means reduced fertility or that it is merely a cosmetic issue (changes in physical features). However, women with PCOS are at a higher risk of developing metabolic disturbances like heart disease, type 2 diabetes, high cholesterol, obesity and cancer.

Coming up in this article:

  • How PCOS is diagnosed

  • The role of hormones in PCOS

  • Common medical conditions linked with PCOS

  • Some obvious signs and symptoms of PCOS

  • Which class of medication are prescribed for treatment

  • Definition of 'Metabolic Syndrome'


How Do You Identify PCOS?

There are three very classic features of PCOS and clinically, two of these need to exist for a formal diagnosis:
  1. Hyperandrogenism (excess androgen): hormones responsible for the development of male reproductive activity and male traits like voice change, facial and body hair growth
  2. Ovulation difficulties:
    1. Anovulation: ovaries do not release an egg during a menstrual cycle
    2. Oligoovulation: irregular/infrequent ovulation
  3. Polycystic ovaries: ovaries contain numerous harmless follicles or cysts that can be up to 8mm in size.

Story of the Hormones in PCOS:


                                                           


**Hypothalamus and Pituitary gland are parts of the brain. Hypothalamus releases GnRH into the pituitary. In response, pituitary then releases LH and FSH hormones. These hormones then influence the male and female reproductive system, which finally release testosterone or estrogen and progesterone, respectively.**

  1. Gonadotropin-releasing hormone (GnRH): In PCOS, there is an increased GnRH activity, which causes and increase in the LH and FSH secretion (more of LH than FSH).
  2. Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH): At the beginning of the menstrual cycle (beginning from menstruation), levels of both are in 1:1 ratio. An LH spike occurs 24 hours before ovulation and then comes back to normal levels. In PCOS, women have constantly increased levels of LH and FSH with the ratio of 3:1. There is no LH spike in PCOS, which means there is no ovulation.
  3. Testosterone: Women with PCOS have abnormally high levels of testosterone that naturally suppresses ovulation and menstruation.
  4. Estrogen: Uterus is where the androgens (described above) are converted into estrogen by FSH. In PCOS, where FSH is lower in ratio than LH, these androgens are not converted into estrogen. Thus, resulting in excess androgens and male traits. 

Some Health Issues Linked with PCOS:

  • Infertility with other pregnancy issues: miscarriage, gestational diabetes, preterm labour
  • Obesity/weight gain
  • Heart disease
  • Type 2 Diabetes
  • Dementia
  • Cancers caused by hormonal fluctuations (breast, ovarian, endometrial)
  • Non-alcoholic fatty liver disease (Read here to learn more about fatty liver)
  • Poor joint and bone health

What are Some Signs and Symptoms of PCOS?

  • Fatigue and poor sleep
  • Weight gain that is challenging to manage
  • Hair growth on face, arms, chest, back, abdomen, thumbs and toes
  • Hair loss, especially at the front (male-pattern hair loss)
  • Infertility
  • Acne, skin tags, dark patches of skin on neck
  • Depression & anxiety
  • Pelvic pain with heavy bleeding or very scanty bleeding

What Kind of Medications are Prescribed?

  • Metformin: one of the first medicines prescribed; given for insulin and glucose moderation to control the risk of development of type 2 diabetes.
  • Oral contraceptive pills (OCPs): helps regulate the menstrual cycle.
  • Anti-androgen medications: to control excess androgen; usually given to men for regulating prostate health; used to prevent testosterone surge and its effects to manage excess hair, voice changes and acne.
  • Ovulating medicines: to induce successful ovulation.

Metabolic Syndrome and PCOS:

Metabolic syndrome is a cluster of conditions listed below that are very closed associated with PCOS and require medical attention (approximately 30-75% of women with PCOS have metabolic syndrome)
  • Central obesity (belly fat): BMI more than 30
  • Abnormal cholesterol and triglyceride levels: HDL (good cholesterol) <35mg/dL and triglyceride >150mg/dL
  • High blood pressure: >140/>90 mmHg
  • Insulin resistance

This is a general representation in simplified terms of the pathophysiology and biology behind PCOS. Stay tuned for Part 2 of this article that will discuss lifestyle changes, dietary modifications, powerful antioxidants and natural plants/ingredients that help manage PCOS.

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Reference: Dr. Nina Bailey, Igennus Healthcare Nutrition